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Xenical Success Stories
Angela: Glucose intolerance, BMI 31
Angela is 45 years old, weighs 190 lbs, and is 5 feet 6 inches tall. She has a BMI of 31 and suffers from impaired glucose (sugar) tolerance, which means she has a higher risk of acquiring diabetes in the future. Her doctor says she needs to lose weight and get her blood sugar under control in order to lower her risk of developing diabetes. Controlling her blood glucose and losing weight will also help Angela lower her risk of heart disease.
Results with XENICAL
Weight loss with XENICAL plus diet has been shown to improve glucose intolerance by reducing the risk or delaying the progression to diabetes. High blood sugar, or hyperglycemia, is a risk factor for type 2 diabetes and coronary artery disease.
In clinical studies, people treated with XENICAL plus diet had lower blood glucose levels after 1 year of treatment than people treated with diet alone.
Among patients at risk for type 2 diabetes, XENICAL plus diet reduced the risk of progression to type 2 diabetes more than twice as often as diet alone.
In three clinical studies, it was shown that 3.0% of patients at risk progressed to type 2 diabetes with XENICAL plus diet versus 7.6% of patients at risk who progressed to type 2 diabetes with diet alone.
The long-term benefits of orlistat on weight-related illnesses and life expectancy have not been studied.
Nancy: Type 2 diabetes, BMI 34
With a BMI of 34, Nancy is considerably overweight. She's 55 years old and 5 feet 4 inches tall, and weighs 200 lbs. Nancy has type 2 diabetes and is taking medicine for this condition. She's hoping that by losing weight with XENICAL and eating a reduced-calorie diet she will be able to manage her diabetes better and lower her risk of coronary heart disease.
Like so many of us, Nancy is concerned that she'll lose weight only to gain it back later. Fortunately, according to clinical studies, XENICAL can help people lose weight and keep it off. In fact, XENICAL is the only prescription weight-loss drug approved for reducing the risk of regaining weight.
Here's something else that can help Nancy remain committed to her weight-loss plan: weight loss with XENICAL plus diet can help people control their high blood sugar levels. High blood sugar, also called hyperglycemia, is a risk factor for type 2 diabetes and coronary heart disease.
Results with XENICAL
Weight loss with XENICAL plus diet has been shown to reduce insulin levels, improve high blood pressure and reduce cholesterol levels. In clinical studies, people treated with XENICAL and a reduced-calorie diet had lower blood glucose levels after 1 year than people treated with diet alone.
The long-term benefits of orlistat on weight-related illnesses and life expectancy have not been studied.
Karen: High cholesterol, BMI 34
Karen is 31 years old, 5 feet 3 inches tall, and weighs 190 lbs. Her BMI of 34 is well over the healthy limit, and she has high cholesterol, which puts her at a greater risk for developing coronary artery disease. To keep her cholesterol in check, Karen is following a diet that's lower in fat and cholesterol. Weight loss with XENICAL, along with a nutritionally balanced, reduced-calorie diet can help her further control her cholesterol. This may lower her cardiovascular risk. And, because Karen and her doctor are concerned about her developing diabetes, she'd like to decrease her blood glucose levels too.
Results with XENICAL
Weight loss with XENICAL plus diet has been shown to significantly lower total and LDL cholesterol ("bad cholesterol") levels and improve the LDL/HDL ratio. Weight loss with XENICAL plus diet also has been shown to reduce insulin levels.
Among patients with elevated LDL cholesterol levels, 1 year of treatment with XENICAL plus diet led to a reduction in LDL cholesterol of 9% compared to the effect of diet alone. In addition, LDL/HDL ratios improved by 39% in patients on XENICAL plus diet versus patients on diet alone.
In an analysis of over 458 people who were enrolled in three clinical studies, people treated with XENICAL and a reduced-calorie diet were 50% less likely to develop type 2 diabetes or glucose intolerance than people treated with diet alone.
The long-term benefits of orlistat on weight-related illnesses and life expectancy have not been studied.
Rene: High blood pressure, BMI 30
At age 49, Rene is 5 feet 7 inches tall, weighs 189 lbs and has a BMI of 30 - which makes her considerably overweight and at risk for obesity-related medical problems. Rene already suffers from severe hypertension (high blood pressure), which she's treating with medicines prescribed by her doctor.
Her high blood pressure is dangerous because it increases her chances of acquiring heart disease, stroke and kidney problems. However, even modest weight loss - 5% to 10% of body weight - can help Rene improve her cardiovascular health by limiting risk factors like elevated blood pressure.
Results with XENICAL
Weight loss with XENICAL plus diet has been shown to improve both systolic and diastolic blood pressures (the top and bottom numbers) in patients with elevated blood pressure to a greater extent than with diet alone.
In clinical studies of patients with high systolic blood pressure and normal diastolic blood pressure, weight loss following 1 year of treatment with XENICAL plus diet was associated with an average reduction in systolic pressure of 5 mm Hg more than with diet alone.
Among patients with elevated diastolic blood pressure, weight loss following 1 year of treatment with XENICAL plus diet was associated with an average reduction in diastolic blood pressure of 2.4 mm Hg more than diet alone.
The long-term benefits of orlistat on weight-related illnesses and life expectancy have not been studied.
Frank: Diabetes, high blood pressure, BMI 29
Frank is 44 years old, 5 feet 8 inches tall, and weighs 190 lbs. This means his BMI is 29. A BMI of 27 or higher is considered overweight.
Frank is taking a prescription medicine to help manage his type 2 diabetes. He also has hypertension (high blood pressure). Both hypertension and diabetes are conditions that can improve with weight loss.
First and foremost, Frank wants to get his diabetes under control. His doctor told him about the importance of changing his dietary habits and activity level. The doctor described the link between being overweight and having type 2 diabetes, and told Frank that he may be able to manage his diabetes with less medicine if he lost weight. Diabetes increases Frank's risk of other medical conditions, including heart disease, nerve damage, vision problems and kidney disease. By shedding extra pounds, Frank may be able to reduce his risks for these complications.
Frank has a number of health-related goals - goals that a combination of XENICAL and a reduced-calorie diet can help him achieve.
Results with XENICAL
Weight loss with XENICAL plus diet has been shown to reduce the risk or delay the progression of impaired glucose tolerance and improve high blood pressure.
In a study of patients who were being treated with oral medication for their type 2 diabetes, those treated with XENICAL plus diet lost 14 lbs of body weight, while those on diet alone lost only 9 lbs after 1 year. In addition, the patients' doctors were able to reduce or discontinue the dose of their diabetes medication in almost 43% of patients on XENICAL plus diet compared to 29% of patients on diet alone.
Note: Do not change or discontinue your use of any prescribed medication without checking with your doctor.
The long-term benefits of orlistat on weight-related illnesses and life expectancy have not been studied.
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