Xenical: diet drug
slowly builds momentum
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One month after the debut of
Hoffman-La Roche's weight-loss drug, Xenical, it is clear that
the drug "will not go down as the most successful new
pharmaceutical in history, but analysts remain confident that
it will become a best seller," the New York Times
reports.
The drug, approved by the FDA in
April, sold 96,485 prescriptions in its first four weeks of
sales -- a paltry performance compared to Viagra's 367,857 and
arthritis drug Celebrex's 150,113 sales during their first
months on the market. "It's important that momentum for
Xenical not peak too early," said Viren Mehta, a partner at
Mehta Partners, adding, "You want to have an educated group of
physicians about the drug."
Xenical, which blocks fat
absorption, reminds many of fen-phen, "a weight loss drug
cocktail that was removed from the market in 1997 over
concerns it caused heart valve damage." Further raising
consumer hesitance, Xenical's side effects include fecal
incontinence, and the drug boasts only modest weight
loss.
However, Dr. Louis Aronne,
director of the Comprehensive Weight Control Program at New
York Hospital-Cornell Medical Center, noted that Xenical "does
something other diet drugs don't do ... You can use it to
treat obese people and not worry about it causing
cardiovascular side effects."
Hoffman-La Roche, which has
already deployed a team of 2,000 Xenical marketers, expects to
begin direct-to-consumer advertising during the third quarter
of this year, and analysts predict sales will "hit $750
million to $1 billion at their peak." "Sales will be erratic,"
Neil Sweig, a Southern Research Partners analyst, said,
adding, "People who take this type of drug are never
satisfied. They want the easy way out to lose weight. In this
market, there is not any loyalty here" (Morrow,
6/2).